A structure for deoxyribose nucleic acid.

Structural Biochemistry/Nucleic Acid/DNA/DNA structure

Deoxyribonucleic acid (DNA) stores information for the synthesis of specific proteins. DNA has deoxyribose as its sugar. DNA consists of a phosphate group, a sugar, and a nitrogenous base. The structure of DNA is a helical, double-stranded macromolecule with bases projecting into the interior of the molecule. These two strands are always complementary in sequence. One strand serves as a templat...

Early nucleic acid chemistry.

,g i:. The contemporary biochemist, perusing the publications of the past century, may easily be misled into some arrogance when sorting out the erroneous data and leads, the slow progress and the primitive reports of that early period. However, when recalling the limited techniques and the lack of facilities at the early stages of biochemistry, he will change his mind. The difficulties encount...

[Nucleic acids].

E wish to suggest a structure for the salt of deoxyribose nucleic acid (D.N.A.). This structure has novel features which are of considerable biological interest. A structure for nucleic acid has already been proposed by Pauling and Corey. They kindly made their manuscript available to us in advance of publication. Their model consists of three intertwined chains, with the phosphates near the fi...

ACTH Adrenocorticotropic hormone CRF/CRH Corticotrophin releasing factor/hormone DALY Disability-adjusted life years DHEA Dehydroepiandrosterone DHEAS Dehydroepiandrosterone sulfate DNA Deoxyribose nucleic acid FSH Follicle stimulating hormone GH Growth hormone GHRH Growth hormone releasing hormone GnRH Gonadotropin releasing hormone HPA Hypothalamo–pituitary–adrenal axis

P Nmr and Two-dimensional Nmr Spectra of Nucleic Acids and 2d Noesy-constrained Molecular Mechanics Calculations for Structural Solution of Duplex Oligonucleotides*

Nuclear magnetic resonance spectroscopy is now able to provide detailed 3-dimensional structures and dynamics of oligonucleotide duplexes and nucleic acid complexes (1,2). Unfortunately, of the six torsional angles that largely define the backbone structure, only the four involving the deoxyribose ring have been shown to be directly amenable to analysis by NMR techniques. In fact for modest-siz...